Why Participate in a Clinical Trial?

Ages: 60-84

• Apparently healthy volunteer (no cancer history)
• Planned to undergo a screening colonoscopy or have not received a colonoscopy in the previous 9 years

Location: Hamden Site

Ages: 18+

• Have a diagnosis of Diabetes
• Have NOT used a CGM:
  continuously for more than 1 week in the last 6 months OR continuously for at least 4 weeks in the last 12 months OR 12 weeks total in the past 3 years
• Additional qualification criteria exist

Location: Hamden Site

Ages: 18+

• Diagnosis of type 2 diabetes
• Have an HbA1c value of 7.0% to 10.0%, inclusive
• Body Mass Index (BMI) less than or equal to 45kg/m²
• Additional qualification criteria exist

Location: Hamden Site

Ages: 18+

• Have a diagnosis of type 2 diabetes
• Have an HbA1c value of 7.5% to 10.5%, inclusive
• Body Mass Index (BMI) ≤ 45 kg/m²
• Additional qualification criteria exist

Location: Waterbury Site

Ages: 18+

• Have a diagnosis of type 2 diabetes
• Have an HbA1c value of 7.0% to 10.0%, inclusive
• Body Mass Index (BMI) ≤ 45 kg/m²
• Additional qualification criteria exist

Location: Waterbury Site

Ages: 18+

• Have a diagnosis of type 2 diabetes
• Have an HbA1c value of ≥6.5% (≥48 mmol/mol) to ≤9.0%
• Body Mass Index (BMI) ≤ 25 kg/m²
• Additional qualification criteria exist

Location: Waterbury Site

Ages: 18+

• 18 years of age or older
• Diagnosis of chronic kidney disease
• Have type 2 diabetes
• Have decreased renal function
• Additional qualification criteria exist

Location: Waterbury Site

Ages: 18+

• Have a diagnosis of type 2 diabetes
• Have an HbA1c value of 7.0% to 10.5%, inclusive (NOT on a sulfonylurea)
  OR
  Have an HbA1c value of 7.5% to 10.5%, inclusive (on a sulfonylurea)
• Body Mass Index (BMI) ≥ 27 kg/m²
• Additional qualification criteria exist

Location: Hamden Site

Ages: 18+

• Have a history of high blood pressure
• Currently on 2-5 blood pressure medications
• Body Mass Index (BMI) 18-40 kg/m²
• Additional qualification criteria exist

Location: Hamden Site

Ages: 40+

• Have high cholesterol
• Body Mass Index (BMI) 18.5 to 40kg/m²
• Additional qualification criteria exist

Location: Waterbury Site

Ages: 40+

• Have had a heart attack, stroke, or symptomatic blockage in the arteries of the lower extremities
• Must be on a well-tolerated statin therapy
• Additional qualification criteria exist

Location: Waterbury Site

Ages: 18+

• Diagnosis of migraine
• Onset of migraines prior to age 50
• Have migraines of moderate to severe intensity within the past 3 months
• Additional qualification criteria exist

Location: Waterbury & Hamden Sites

Ages: 18+

• Diagnosis of migraine
• Onset of migraines prior to age 50
• Must have 4 to 14 migraines per month
• Additional qualification criteria exist

Location: Waterbury Site

Ages: 40+

• Body Mass Index (BMI) greater than or equal to 27kg/m²
• Have had a heart attack, stroke, or symptomatic blockage in the arteries of the lower extremities
  
  OR
  
  Have CV risk factors (e.g. high blood pressure, high cholesterol, kidney disease, prediabetes)
  
• Additional qualification criteria exist

Location: Waterbury Site

Ages: 18-35

• Healthy adult female, 18-35 years of age, inclusive
• Must be postmenarcheal and premenopausal
• Additional qualification criteria exist

Location: Hamden Site

Ages: 18+

• Diagnosis of knee osteoarthritis
• Body Mass Index (BMI) of ≥18.0 to ≤35.0 kg/m²
• Additional qualification criteria exist

Location: Waterbury Site

Ages: 60+

• Additional qualification criteria exist

Location: Hamden Site

Ages: 18+

• Adult participants
• Additional qualification criteria exist

Location: Waterbury Site